Davalos V, Lovell CD, Von Itter R, Dolgalev I, Agrawal P, Baptiste G, Kahler DJ, Sokolova E, Moran S, Piqué L, Vega-Saenz de Miera E, Fontanals-Cirera B, Karz A, Tsirigos A, Yun C, Darvishian F, Etchevers HC, Osman I, Esteller M, Schober M, Hernando E. An epigenetic switch controls an alternative NR2F2 isoform that unleashes a metastatic program in melanoma. Nat Commun. 2023 Apr 4;14(1):1867. doi: 10.1038/s41467-023-36967-2.PMID: 37015919 

Biermann J, Melms JC, Amin AD, Wang Y, Caprio LA, Karz A, Tagore S, Barrera I, Ibarra-Arellano MA, Andreatta M, Fullerton BT, Gretarsson KH, Sahu V, Mangipudy VS, Nguyen TTT, Nair A, Rogava M, Ho P, Koch PD, Banu M, Humala N, Mahajan A, Walsh ZH, Shah SB, Vaccaro DH, Caldwell B, Mu M, Wünnemann F, Chazotte M, Berhe S, Luoma AM, Driver J, Ingham M, Khan SA, Rapisuwon S, Slingluff CL Jr, Eigentler T, Röcken M, Carvajal R, Atkins MB, Davies MA, Agustinus A, Bakhoum SF, Azizi E, Siegelin M, Lu C, Carmona SJ, Hibshoosh H, Ribas A, Canoll P, Bruce JN, Bi WL, Agrawal P, Schapiro D, Hernando E, Macosko EZ, Chen F, Schwartz GK, Izar B. Dissecting the treatment-naive ecosystem of human melanoma brain metastasis. Cell. 2022 Jul 7;185(14):2591-2608.e30. doi: 10.1016/j.cell.2022.06.007.PMID: 35803246

Steele MM, Jaiswal A, Delclaux I, Dryg ID, Murugan D, Femel J, Son S, du Bois H, Hill C, Leachman SA, Chang YH, Coussens LM, Anandasabapathy N, Lund AW. T cell egress via lymphatic vessels is tuned by antigen encounter and limits tumor control. Nat Immunol. 2023 Apr;24(4):664-675. doi: 10.1038/s41590-023-01443-y. Epub 2023 Feb 27.PMID: 36849745

Barkley D, Moncada R, Pour M, Liberman DA, Dryg I, Werba G, Wang W, Baron M, Rao A, Xia B, França GS, Weil A, Delair DF, Hajdu C, Lund AW, Osman I, Yanai I. Cancer cell states recur across tumor types and form specific interactions with the tumor microenvironment. Nat Genet. 2022 Aug;54(8):1192-1201. doi: 10.1038/s41588-022-01141-9. Epub 2022 Aug 5.PMID: 35931863 

Sun Q, Lee W, Hu H, Ogawa T, De Leon S, Katehis I, Lim CH, Takeo M, Cammer M, Taketo MM, Gay DL, Millar SE, Ito M. Dedifferentiation maintains melanocyte stem cells in a dynamic niche. Nature. 2023 Apr 19. doi: 10.1038/s41586-023-05960-6. Online ahead of print.PMID: 37076619

Johannet P, Simons M, Qian Y, Azmy N, Mehnert JM, Weber JS, Zhong J, Osman I. Risk and tropism of central nervous system (CNS) metastases in patients with stage II and III cutaneous melanoma.  Cancer. 2022 Oct;128(20):3620-3629. doi: 10.1002/cncr.34435. Epub 2022 Aug 25.PMID: 36006879

ung TN, Shafi S, Wilmott JS, Nourmohammadi S, Vathiotis I, Gavrielatou N, Fernandez A, Yaghoobi V, Sinnberg T, Amaral T, Ikenberg K, Khosrotehrani K, Osman I, Acs B, Bai Y, Martinez-Morilla S, Moutafi M, Thompson JF, Scolyer RA, Rimm DL. Objective assessment of tumor infiltrating lymphocytes as a prognostic marker in melanoma using machine learning algorithms. AEBioMedicine. 2022 Aug;82:104143. doi: 10.1016/j.ebiom.2022.104143. Epub 2022 Jul 7.PMID: 35810563

Coudray N, Jour G, Dawood Z, Hong R, Esteva E, Sakellaropoulos T, Donnelly D, Moran U, Hatzimemos A, Weber JS, Razavian N, Aifantis I, Fenyo D, Snuderl M, Shapiro R, Berman RS, Osman I, Tsirigos A. Deep Learning and Pathomics Analyses Reveal Cell Nuclei as Important Features for Mutation Prediction of BRAF-Mutated Melanomas. Kim RH, Nomikou S, J Invest Dermatol. 2022 Jun;142(6):1650-1658.e6. doi: 10.1016/j.jid.2021.09.034. Epub 2021 Oct 30.PMID: 34757067Steele, MM., Jaiswal, A., Delclaux, I., Dryg, ID., Murugan, D., Femel, J., Son, S., du Bois, H., Hill, C., Leachman, SA., Chang, YH., Coussens, LM., Anandasabapathy, N., Lund, AW. T cell egress via lymphatic vessels is tuned by antigen encounter and limits tumor control. 2023. Nature Immunol. doi.org/10.1038/s41590-023-01443-y

Werba, G., Weissinger, D., Kawaler, E.A., Zhao, E., Kalfakakou, D., Dhara, S., Oh, G., Beri, N., Khanna, L., Gonda, T., Oberstein, P., Hajdu, C., Loomis, C., Heguy, A., Sherman, MH., Lund, AW., Welling, TH., Dolgalev, I., Tsirigos, A., Simeone, DM. Single-cell sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment. 2023. Nature Communications. 14:797. Doi:10.1038/s41467-023-36296-4.

Kleffman K, Levinson G, Rose IVL, Blumenberg L, Shadaloey SAA, Dhabaria A, Wong E, Galán-Echevarría F, Karz A, Argibay D, Von-Itter R, Floristán A, Baptiste G, Eskow N, Tranos J, Chen J, de Miera ECVS, Call M, Rogers R, Jour G, Wadghiri YZ, Osman I, Li YM, Mathews P, DeMattos R, Ueberheide B, Ruggles KV, Liddelow SA, Schneider RJ, Hernando E, (2022) Melanoma-secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis. Cancer Discovery. PMID: 35262173

Barkley, D., Moncada, R., Pour, M., Liberman, DA., Dryg, ID., Werba, G., Wang, W., Baron, M., Rao, A., Xia, B., Franca, GS., Weil, A., Delair, DF., Hajdu, C., Lund, AW., Osman, I., Yanai, I. Cancer cell states recur across tumor types and form specific interactions with the tumor microenvironment. 2022. Nature Genetics. Aug;54(8):1192-1201 doi:10.1038/s41588-022-01141-9.

Churchill, MJ., du Bois, H., Heim, TA., Mudianto, T., Steele, MM., Nolz, JC., and Lund, AW. Infection-induced lymphatic zippering restricts fluid transport and viral dissemination from skin. 2022. Journal of Experimental Medicine. 219(5): e20211830. doi: 10.1084/jem.20211830.

Lund, AW. Immune Potential Untapped: Leveraging the Lymphatic System for Cancer Immunotherapy. 2022. Cancer Immunology Research. https://doi.org/10.1158/2326-6066.CIR-22-0266. Rising Stars in Cancer Immunology Series

Marin-Bejar, O., Rogiers, A., Dewaele, M., Femel, J., Karras, P., Pozniak, J., Bervoets, G., Van Raemdonck, N., Pedri, D., Swings, T., Demeulemeester, J., Vander Borght, S., Bosiso, F., van den Oord, J.J., Vanden Bempt, I., Lambrechts, D., Voet, T., Bechter, O., Rizos, H., Levesque, M., Leucci, E., Lund, A.W., Rambow, F., Marine, J.C. Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma. 2021. Cancer Cell. Aug 9;39(8):1135-1149.e8. doi10.106/j.ccell.2021.05.015.

Steele, M.M., and Lund, A.W. Afferent lymphatic transport and peripheral tissue immunity. 2021. The Journal of Immunology. Jan. 206 (2) 264-272. doi:10.4049/jimmunol.2001060.

Patton, L., Mueller, K., Anandasabapathy, N., Aplin, A., Corine, B., Bosenberg, M,. Ceol, C., Herlyn, M., Holmen, S., Karreth, F., Kebold, S., Kaufman, C., Khan, S., Leucci, E., Levy, C., Lombard, D., Lund, A.W., Marie, K., Marine, J.C., Marais, R., McMahon, M., Robles-Espinoza, D., Ronai, Z., Samuels, Y., Soengas., M.M., Villaneuva, J., Weeraratna, A., White, R., Yeh, I., Zhu, J., Zon, L., Hulbert, M., Merlino, G. Melanoma Models for the Next Generation of Therapies. 2021 Cancer Cell. doi.org/10.1016.j.ccell.2021.01.011.

du Bois, H.#, Heim, T.A.#, Lund, AW. The tumor-draining lymph node: The crossroads of metastasis and immunity. 2021. Science Immunology. 6(63). doi:10.1126/sciimmunol.abg3551. Cover Feature

Steele, M.M., Churchill, M.J., Breazeale, A.P., Lane, R.S., Nelson, N.A., Lund, A.W. Quantifying leukocyte egress from murine skin and tumors. 2019 Journal of Visual Experiments (143) e58704, doi:10.3791/58704.

Sastre-Perona A, Hoang-Phou S, Leitner M, Okuniewska M, Meehan S and Schober M. De Novo PITX1 Expression Controls Bi-Stable Transcriptional Circuits to Govern Self-Renewal and Differentiation in Squamous Cell Carcinoma. Cell Stem Cell. 2019 Mar 7;24(3):390-404.e8. PMCID: PMC7081946.

Sun Q, Lee W, Gay D, Takeo M, Lim CH, Xu X, Myung P, Atit RP, Taketo MM, Moubarak RS, Schober M, Osman I, Nishimura EK, and Ito M. A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease. Nature Communications. 2019. Nov 4; 10(1)5023.

Rambow, F., Rogiers, A., Marin-Bejar, O., Aibar, S., Femel, J., Dewaele, M., Karras, P., Brown, D., Chang, Y.H., Debiec-Rychter, M., Adriaens, C., Radaelli, E., Wolter, P., Bechter, O., Dummer, R., Levesque, M., Piris, A., Frederick, D.T., Boland, G., Flaherty, K.T., van den Oord, J.J., Voet, T., Aerts, S., Lund, A.W., Marine, J.C. Towards minimal residual disease-directed therapy in melanoma. 2018 Cell. Aug 9; 174(4):843-855.e19.

Lane, R.S., Femel, J., Breazeale, A.P., Loo, C.P., Thibault, G., Kaempf, A., Mori, M., Tsujikawa, T., Chang, Y.H., Lund, A.W. IFNγ activated dermal lymphatic vessels inhibit cytotoxic T cells in melanoma and inflamed skin. 2018 Journal of Experimental Medicine Oct 31. 21;215(12):3057. doi: 10.1084/jem.20180654 Highlighted by Nature Reviews Cancer

Brown JA, Yonekubo Y, Hanson N, Sastre-Perona A, Basin A, Rytlewski JA, Dolgalev I, Meehan S, Tsirigos A, Beronja S, Schober M. TGFβ-induced quiescence mediates chemoresistance of tumor propagating cells in squamous cell carcinoma. Cell Stem Cell. 2017. Nov 2;21(5):650-664.e8. PMCID: PMC5778452.

Fankhauser, M., Broggi, M.A.S., Potin, L., Bordry, N., Jeanbart, L., Lund, AW., Da Costa, E., Hauert, S., Rincon, M., Tremblay, C., Cabellow, E., Homicsko, K., Michelin, O., Hanahan, D., Speiser, D.E., and Swartz, M.A. Tumor lymphangiogenesis promotes T cell infiltration and potentiates immunotherapy in melanoma. 2017 Science and Translational Medicine Sep;9(407), eaaI4712.

Loo, C.#, Nelson, N.A.#, Lane, R.S., Booth, J.L., Loprinzi Hardin, S.C., Thomas, A., Slifka, M.K., Nolz, J.C., Lund, A.W. Lymphatic vessels balance viral dissemination and immune activation following cutaneous viral infection. 2017 Cell Reports. Sep 26;20(123):3176-3187.

Lund, A.W., Wagner, M., Fankhauser, M., Alitalo, K., Eikesdal, H.P., Wiig, H., Swartz, M.A. Lymphatic vessels regulate immune microenvironments in human and murine melanoma. Journal of Clinical Investigation. 2016 126(9):3389-3402.

Thomas S.N., Vokali, E., Lund, A.W., Hubbell, J.A., Swartz, M.A. Targeting the tumor draining lymph node with adjuvanted nanoparticles reshapes the anti-tumor immune response. Biomaterials. 2014 Jan;35(2):814-24.

Hirosue, S., Vokali, E., Raghavan, V., Rincon-Restrepo, M., Lund, A.W., Corthesy-Henrioud, P., Capotosti, F., Halin Winter, C., Hugues, S., Swartz, M.A. Steady-state antigen scavenging, cross-presentation and CD8+ T cell priming: a new role for lymphatic endothelial cells. Journal of Immunology. 2014 June 1;192(11):5002-11.

Lund, A.W., Duraes, F.V., Hirosue, S., Raghavan, V.R.,Thomas, S.N., Nembrini, C., Issa, A., Hugues, S., Swartz, M.A. VEGF-C promotes immune tolerance in B16 melanomas and cross-presentation of tumor antigen by lymph node lymphatics. Cell Reports. 2012 Feb 1(3):191-199.                                           

M.A. Swartz and Lund, A.W. Lymphatic and interstitial flow in the tumor microenvironment: Linking tumor mechanobiology with lymph node immunity. Nature Reviews Cancer. 2012 Feb 24;12(3):201-9.

Lund, A.W. Re-thinking lymphatic vessels and anti-tumor immunity. TRENDs in Cancer. 2016 Sept 24. doi:10.1016/j.trecan.2016.09.005.